In 1995, at the age of 20, Karrie won the Women's British Open for the first time.

She joined the USLPGA Tour the following year and won four times that year. In her rookie year, she was awarded the LPGA Rookie of the Year and was at the top of the money list by becoming the first LPGA player to win $1 million mark in a single season. She continued to win and in 2001 she achieved the Grand Slam. Around 2003, she began to modify her swing to achieve even greater success. Around the same time, she had a fateful meeting with N.S.PRO. In 2006, she and N.S. PRO won five top tournaments in one year, including one major championship.

Karrie has continued to win numerous titles, with a total of 59 wins (7 major championships) and three times as Money Leader. At that time, Karrie was the youngest player ever to be inducted into the World Golf Hall of Fame and is highly respected by professional golfers around the world. In recent years, she has been appointed as the Australian coach (general director) for the 2024 Paris Olympics. Karrie is also involved in junior training and golf course design in Australia, expanding her activities beyond the game. With N.S.PRO as a good partner, Karrie Webb will continue to leave her mark on the history of golf.